Since 2011, we are focusing on the origin, evolution and function of brown adipose tissue (BAT) which is coincidence with the "one three five" planning objectives number three: the animal evolution and conservation. The BAT is a key factor of thermoregulation in mammals. The main function of BAT is the regulation of thermogenesis since BAT can produce heat 60 times more than liver, and 10 times more than muscle. Mammals can keep body temperature within a constant range（35-38°C）even in the change of ambient temperature. Homeotherms can maintain their body temperature relatively independent of ambient temperature, thus allowing them to adapt to various environments. Therefore, acquisitions of novel physiological mechanisms for the regulation of body temperature is critical for the wide distribution of homeotherms in the biosphere, and these physiological mechanisms are thought to have evolved after acquisition of homeothermy.

Our ultimate scientific goals are then investigate a) evolutionary meaning of brown adipose tissue, b) origins of brown adipose tissue across species, c) regulatory network of BAT specific genes across species. To address these issues, we will carry out multi-dimensional researches by using small molecules libraries, primary and cell line cells, genetically modified mice models and other disease animal models. We believe it will give us potential clues to prevent and treat obesity and its related disease.