Regulation of Energy Metabolism Group —— Principal Investigator
Wanzhu Jin
Regulation of Energy Metabolism
Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1Beichen West Road, Chaoyang District, Beijing 100101, P.R
Regulation of Energy Metabolism Group    中文

Wanzhu Jin, Group leader of Regulation of Energy Metabolism Group;Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China. 1990-1994, BSc. Department of Veterinary Medicine,Yanbian University,Jilin.

1999-2003, Ph.D. United Graduate School of Veterinary Sciences, Gifu University, Japan

1990-1994, BSc. Department of Veterinary Medicine,Yanbian University,Jilin.

Professional Experience:

2010-, Professor at Institute of Zoology, Chinese Academy of Sciences

2006-2010, Postdoc,Harvard Medical School

2003-2006, Postdoc Riken Institute, Japan

Research Interests:

Research Interests

(1)Molecular mechanism of brown adipose tissue activator

The activity of brown adipose tissue is negatively correlated with body mass index (BMI). An effective way to activate brown adipose tissue could offer a novel way to prevent or treat obesity.

(2)The functional evolutionary regulatory network of brown adipose tissue

By combining genomic and transcriptome data, they explore the origin, evolutionary significance, and regulatory network of brown adipose tissue. The related target genes provide reference for the prevention and treatment of obesity and diabetes.

(3)Oral drug delivery system

Compared with traditional antibody drug delivery system, probiotics oral drug delivery system has the following advantages: low cost, high safety and non-toxic side effects. The liquid or solid recombinant probiotics preparation can be taken orally without injection to improve medical compliance.

Selected Publications:
  • Linhu Quan#, Chuanhai Zhang#, Meng Dong#, Jun Jiang#, Hongde Xu#, chunlong Yan#, Xiaomeng liu, Huiqiao Zhou, Hanlin Zhang, Li Chen,Fei liang Zhong, Zhaobo luo, Sin Man lam, Guanghou Shui, Donghao li*, Wanzhu Jin*.Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2019; 0:1–9.
  • Na Yin #, Hanlin Zhang,Rongcai Ye, Meng Dong,Jun Lin,Huiqiao Zhou,Yuanyuan Huang,Li Chen,Xiaoxiao Jiang,Kentaro Nagaoka , Chuanhai Zhang*,and Wanzhu Jin*. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. Int J Mol Sci. 2019 Apr 1,20(7). pii: E1622. 
  • Zheng Q#, Lin J#,  Huang J#, Zhang HZhang RZhang XCao CHambly CQin GYao JSong RJia QWang XLi YZhang NPiao ZYe RSpeakman JRWang HZhou QWang Y*, Jin W*Zhao J*. Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity. PNAS.2017,114(45): E9474-E9482.
  • Hu T#, Yuan X, Wei G, Luo H*,Lee HJ*, Jin W*.Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice. Eur J Nutr. 2018.57(1):391-403.
  • Yilin You#, Xiaoxue Yuan#, Xiaomeng Liu#, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun,Tingting Ma, Guojie Liu, Wanzhu Jin*,Weidong Huang*and Jicheng Zhan*.Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function .Mol Nutr& Food Res.2017.61(11): 1-13.
  • Hu T#, Yuan X#, Ye R #, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W*. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. JNB.2017.47:21-28.
  • Rong Wu#, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li , John R Speakman, Guang Ning, Wanzhu Jin*, Zengqiang Yuan*. DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discovery (2017) 3, 16054:1-18.
  • Lin J#, Cao C#, Tao C#, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C,Li K,Speakman J,Wang Y*,Jin W*,Zhao J*. Cold adaptation in pigs depends on UCP 3 in beige adipocytes. JMCB. 2017. 9(5):364-375.
  • Yuan X#, Wei G#, You Y#, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W*. Rutin ameliorates obesity through brown fat activation. the Faseb journal .2017. 31(1):333-345.
  • Wu R#, Sun JGWang JQLi BLiu QNing GJin W*Yuan Z*. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. Diabetologia. 2017. 60(5):900-910.
  • Zhang C#, Weng YShi FJin W*.The Engrailed-1 Gene Stimulates Brown Adipogenesis .Stem Cells Int.  2016:7369491.
  • Xiaoxue Yuan#, Tao Hu#, Han Zhao#, Yuanyuan Huang, Rongcai Ye, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang wei, Huiqiao Zhou, Meng Dong , Jun Zhao, Haibin Wang, Qingsong Liu , Hyuek-Jong Lee, Wanzhu Jin* and Zi-Jiang Chen*. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.PNAS.2016,113(10): 2708–2713.
  • Liu X#, Wang S#, You Y#, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W*. Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice. Endocrinology, 2015, 156 (7): 2461-2469.
  • Yanyan Shen#,Xiaomeng Liu, Meng Dong ,Jun Lin,Qianwei Zhao,HyuekJong Lee,Wanzhu Jin*. Recent advances in brown adipose tissue biology. Chin. Sci. Bull. 2014,59(31):4030–4040.
  • Liu X#, Zheng Z, Zhu X, Meng M, Li L, Shen Y, Chi Q, Wang D, Zhang Z, Li C, Li Y, Xue Y, Speakman J and Jin W*. Brown adipose tissue transplantation improves whole-body energy metabolism. Cell Research, 2013, 23(6): 851-854.
  • Jin W# ,Goldfine A,Boes T,Henry R,Ciaraldi T, Kim EYEmecan MFitzpatrick CSen AShah AMun EVokes VSchroeder JTatro EJimenez-Chillaron JPatti ME*,Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice,J Clin Invest,2011, 121(3):918-929
  • Jin W# ,Patti ME*,Genetic determinants and molecular pathways in the pathogenesis of diabetes, Clin Sci, 2009, 116(2):99-111
  • Jin W# ,Takagi T, Kanesashi S, Kurahashi T,Nomura T,Harada J,Ishii S*, Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins,Developmental Cell,2006,10(4);461-471


  • Patti ME,Wanzhu Jin,Goldfine A,Inhibiting Serun Response Factor (SRF) to Improve Glycemic Control,2009.6,美国,US8003606
  • Patti ME,Wanzhu Jin,Goldfine A,Inhibiting Striated Muscle Activator of Rho Signaling (STARS),2011.6,国际,PCT/US2011/039059


  • The National Natural Science Foundation of China,81770834,The interaction between lymphatic system and obesity and its mechanism, 2018/01-2021/12
  • The National Natural Science Foundation of China,81171131,Molecular mechanism of STARS-SRF signaling pathway controls lipid metabolism, 2011/01-2013/12
  • The National Natural Science Foundation of China,81370951,microRNA mediated browning of white adipose tissue,2014/01-2017.12
  • National Key Research and Development Program of China,2017YFC1001003,Model animals were used to evaluate the effectiveness and safety of interventions with different subtypes of PCOS,2017/07-2020/12
  • National Natural Science Foundation of China,2012CB944701,Research on the pathogenesis of ovulatory disorders,2012/01-2016/8 
  • National Natural Science Foundation of China, 2012CBA01301,The research of cellular pluripotency in primates2012/01-2016/8 
  • The Strategic Priority Research Program from the Chinese Academy of Sciences,KJZD-EW-L01-3,Frontier research of non-coding RNA,2013/01-2015/12
  • The Strategic Priority Research Program from the Chinese Academy of Sciences,XDB13030000,The origin and evolution of brown adipose tissue,2014/07-2019/6