Ecotoxicology Group —— Principal Investigator
DAI, Jia-Yin
Biochemistry and Molecular Biology
+86-10-64807185  / 
Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
Group of Ecotoxicology    中文

Prof. Jiayin Dai, Leader of ecotoxicology research group; Vice Director of Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.

Ph.D., 1999, Environmental Biology, Department of Environmental Science and Engineering, Nanjing University, Nanjing, China. Thesis Title: "Quantitative structure-activity toxicity relationship for organic compounds".

M.S., 1996, Biochemistry, Department of Biochemistry, Xiamen University, Xiamen, China. Thesis Title: "Accumulation of heavy metal and pesticide and Effect on Activities of Catalase and GPT in the Clam Ruditapes philippinarum A.".

B.S., 1988, Biochemistry and Microbiology, Department of Biology, Anhui University, Anhui, China.

Work experience: 

2001.10-2005.4 Postdoc, Department of Biochemistry, the Weill Medical College of Cornell University,

2000.10-2001.10 Postdoc, Department of Human Biological Chemistry & Genetic, the University of Texas Medical Branch at Galveston,

1999.7-2000.10 Postdoc, State Key Laboratory of Pollution Control Resource and Reuse, the Tongji University,

1988-1993 Lecturer, Anhui Science and Technology College, Taught Biochemistry and Microbiology.

Research Interests:

Environmental fate, ecotoxicological effects, and toxic mechanism of persistent organic pollutants (POPs). Focused on the environmental distribution and process of persistent organic pollutants, such as perfluorochemicals and halogenated compounds, the response of species to pollutants on molecular, cellular, organismal and community levels; investigate the transcriptional and translational alterations of genes and their regulation under stress environments using genomic and proteomic analysis method; look for potential cellular and molecular biomarkers as diagnostic and prognostic tools for pollution monitoring, as well as degradation methods and technologies for POPs in environment.

Selected Publications:
  • Lina Ding, Fuhua Hao, Zhimin Shi, Yulan Wang, Hongxia Zhang, Huiru Tang, and Jiayin Dai*. (2009) Systemic responses to chronic perfluorododecanoic acid exposure studied by integrated metabonomics and transcriptomics. Journal of Proteome Research, 9, 2882-2991.
  • Xuemei Fang, Yixing Feng, Zhimin Shi and Jiayin Dai*. (2009) Alterations of Cytokines and MAPK Signaling Pathways Are Related to the Immunotoxic Effect of Perfluorononanoic Acid. Toxicological Sciences, 108, 367-376.
  • Zhimin Shi, Lina Ding, Hongxia Zhang, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and related genes expressions in male rat. Toxicology Letters, 188, 192-200.
  • Zhimin Shi, Hongxia Zhang, Lina Ding, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats. Reproductive Toxicology, 27, 352-359.
  • Yang Liu, Jianshe Wang, Yong Liu, Hongxia Zhang, Muqi Xu Jiayin Dai*. (2009) Expression of a novel cytochrome P450 4T gene in rare minnow (Gobiocypris rarus) following perfluorooctanoic acid exposure. Comparative Biochemistry and Physiology, Part C, 150, 57-64.
  • Yixing Feng, Zhimin Shi, Xuemei Fang, Muqi Xu, Jiayin Dai*. (2009) Perfluorononanoic Acid Induces Apoptosis Involving the Fas Death Receptor Signaling Pathway in Rat Testis. Toxicology Letters, DOI: 10.1016/j.toxlet.2009.07.020.
  • Yanhong Wei, Leo. L. Chan, Dazhi Wang, Hongxia Zhang, Jianshe Wang, Jiayin Dai*. (2008) Proteomic Analysis of Hepatic Protein Profiles in Rare Minnow (Gobiocypris rarus) Exposed to Perfluorooctanoic Acid. Journal of Proteome Research, 7, 1729-1739.
  • Guocheng Hu, Xiaojun Luo, Jiayin Dai*, Xiulan Zhang, Hua Wu, Chenglin Zhang, Wei Guo, Muqi Xu, Bixian Mai, Fuwen Wei.(2008) Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 4697-4703.
  • Xuemei Li, Leo W.Y. Yeung, Sachi Taniyasu, Ming Li, Hongxia Zhang, Dan Liu, Paul K.S. Lam, and Jiayin Dai*. (2008) Perfluorooctanesulfonate and Related Fluorochemicals in the Amur Tiger (Panthera tigris altaica) from China. Environmental Science & Technology, 42, 7078-7083.
  • Guocheng Hu, Jiayin Dai*, Muqi Xu, Xiaojun Luo, and Bixian Mai. (2008) Response to Comment on “Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Captive Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 8173-8174.
  • Yanhong Wei, Yang Liu, Jianshe Wang, Yi Tao, Jiayin Dai*. (2008) Toxicogenomic Analysis of the Hepatic Effects of Perfluorooctanoic Acid on Male and Female Rare Minnows(Gobiocypris rarus). Toxicology and Applied Pharmacology, 226, 285-297.
  • Hongxia Zhang, Zhimin Shi, Yang Liu, Yanhong Wei, Jiayin Dai*. (2008) Response of Lipid Homeostasis and Oxidative Stress in the Liver of Male Rats Exposed to Perfluorododecanoic acid. Toxicology and Applied Pharmacology, 227, 16-25.
  • Xuemei Fang, Lianjun Zhang, Yixing Feng, Yong Zhao, Jiayin Dai*. (2008) Immunotoxic Effects of Perfluorononanoic Acid on BALB/c Mice. Toxicological Sciences, 105, 312-21.
  • Xuemei Li, Leo Wai Yin Yeung, Muqi Xu, Sachi Taniyasu, Paul K.S. Lam, Nobuyoshi Yamashita, Jiayin Dai*. (2008). Perfluorooctane sulfonate (PFOS) and other fluorochemicals in zooplankton and fish collected near the outfall of wastewater treatment plant (WWTP) in Beijing. Environmental Pollution, 156, 1298-1303.
  • Yong Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, and Jiayin Dai*. (2008) Molecular characterization of cytochrome P450 3A and 1A and the effects of perfluorooctanoic acid on their expression in rare minnow (Gobiocypris rarus) gills. Aquatic toxicology, 88, 183-190.
  • Yang Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, Muqi Xu, and Jiayin Dai*. (2008) Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquatic toxicology, 89, 242-250.
  • Xuemei Li, Leo Wai Yin Yeung, Sachi Taniyasu, Paul K. S. Lam, Nobuyoshi Yamashita, Muqi Xu, Jiayin Dai*. (2008) Perfluorinated compounds in Bengal tiger (Panthera tigris tigris) and African lion (Panthera leo Linnaeus) in China. Chemosphere, 73, 1649-1653.
  • Jianshe Wang, Yanhong Wei, Dazhi Wang, Leo. L. Chan, and Jiayin Dai*. (2008) Proteomic study of the effects of complex environmental stresses in the livers of goldfish (Carassius auratus) that inhabit Gaobeidian Lake in Beijing, China. Ecotoxicology, 17, 213-220.
  • Jianshe Wang, Zhiyong Feng, Dandan Yao, Jingjing Sui, Wenqing Zhong, Jiayin Dai*. (2008) Warfarin Resistance in Rattus losea in Guangdong Province, China. Pesticide Biochemistry and Physiology, 91, 90-95.
  • Lingling Deng, Muqi Xu, Hong Cao, and Jiayin Dai*. (2008) Ecotoxicological effects of buprofezin on fecundity, growth, development and predation of the wolf spider, PIRATA PIRATOIDES (Schenkel), Archives of Environmental Contamination and Toxicology, 55, 652-658.
  • Xuemei Li, Yiping Gan, Xiangping Yang, Jun Zhou, Jiayin Dai, Muqi Xu. (2008) Human health risk of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in edible fish from Huairou Reservoir and Gaobeidian Lake in Beijing, China. Food Chemistry, 109, 348-354.
  • Xuemei Li, Qinghua Zhang, Jiayin Dai, Yiping Gan, Jun Zhou, Xiangping Yang, Hong Cao, Guibin Jiang, Muqi Xu. (2008) Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian Wastewater Treatment Plant. Chemosphere, 72, 1145-1151.
  • Jun Xu, Min Yang,Jiayin Dai, Hong Cao , Canping Pan, Xinghui Qiu, Muqi Xu. (2008) Degradation of acetochlor by four microbial communities, Bioresource Technology, 99, 7797-7802.